Myelodysplastic syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)
نویسنده
چکیده
Classification The FAB and WHO classifications The French-American-British (FAB) cooperative group produced the first systematic attempt of a classification dividing myelodysplastic syndrome (MDS) into five subgroups: refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)1;2. Distinction among the subtypes was based on the proportion of blasts in the peripheral blood (PB) and bone marrow (BM) and the degree of monocytosis in the blood. The WHO classification of hematological malignancies incorporates clonal cytogenetic abnormalities and lowered the threshold for distinguishing acute myeloid leukemia (AML) from MDS from 30% to 20% of blasts in the BM 3.
منابع مشابه
Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies...
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